Biological monitoring of workers exposed to 4,4'-methylenebis (2-chloroaniline) (MBOCA).
نویسندگان
چکیده
A biological monitoring programme has been developed for assessing occupational exposure to 4,4'-methylenebis (2-chloroaniline) (MBOCA) in a factory which manufactures polyurethane elastomers. In a systematic programme of biological monitoring over a five year period urinary MBOCA concentrations have been used to provide evidence of absorption of MBOCA. Improvements in the handling and use of MBOCA have coincided with a steady reduction in the urinary MBOCA concentrations.
منابع مشابه
Evidence that a beta-N-glucuronide of 4,4'-methylenebis (2-chloroaniline) (MbOCA) is a major urinary metabolite in man: implications for biological monitoring.
Urine samples from workers exposed to 4,4'-methylenebis (2-chloroaniline) (MbOCA) contain a labile metabolite(s) that, on hydrolysis, yields the parent compound at concentrations two to three times those of free MbOCA. Evidence has now been obtained that the major labile metabolite is an N-glucuronide of MbOCA. The N-glucuronide of MbOCA was synthesised chemically, characterised by thermospray ...
متن کاملExposure to 4,4'-methylene bis (2-chloroaniline) (MbOCA) in New South Wales, Australia
OBJECTIVES This study was conducted to determine the level of exposure of 4,4'-methylene bis (2-chloroaniline) (MbOCA) in New South Wales (NSW), Australia. METHODS An integrated occupational hygiene and biological monitoring program were used to assess the workers' exposure to MbOCA via inhalation, ingestion and dermal contact. This was conducted by personal air monitoring, static air monitor...
متن کاملDetermination of 4,4'-methylenebis(2-chloroaniline) in urine by liquid chromatography with ion-paired solid-phase extraction and electrochemical detection.
This highly specific and sensitive method for measuring urinary 4,4'-methylenebis(2-chloroaniline) (MBOCA) involves liquid chromatography with electrochemical detection. Before chromatography, urine samples are prepared by ion-paired solid-phase extraction on a disposable octadecylsilica column with acidic methanol solution containing 1-heptanesulfonic acid. This enhances the specificity of the...
متن کاملDetermination of 4,4'-methylenebis(2-chloroaniline) in urine.
We read with interest the paper by Okayania et al. (1) describing a liquidchromatographic method for measuring 4,4’-methylenebis(2-chloroaniline) (MB0CA) in urine by use of solid-phase extraction and electrochemical detection. For over 10 years we have been involved in the routine monitoring of workers who are exposed to MBOCA. We do this by measuring MBOCA in the urine (2). Initially, we used ...
متن کاملOccupational Bladder Cancer in a 4,4′-Methylenebis(2-chloroaniline) (MBOCA)-Exposed Worker
A 52-year-old male chemical worker was admitted to the hospital with a history of paroxysmal microscopic hematuria for about 2 years and nocturia with gross hematuria about five times per night for 2 months. He was a nonsmoker and denied a history of any other bladder carcinogen exposure except for occasional pesticide application during agricultural work. Intravenous urogram imaging showed a m...
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ورودعنوان ژورنال:
- British journal of industrial medicine
دوره 41 4 شماره
صفحات -
تاریخ انتشار 1984